Return From Pharma Research and Development Innovation

The seventh annual pharmaceutical innovation study, co-produced by the Deloitte Center for Health Solutions in the US and the UK, looks at the challenges the industry faces in generating returns from its R&D investments. The report also highlights key strategies to help increase pipeline value while reducing R&D costs to generate sustainable returns and here are some key points.


Key findings

The pharmaceutical industry continues to face regulatory and reimbursement hurdles weighing on the research and development (R&D) returns of pharmaceutical firms this year.After reviewing the estimated returns of 12 leading biopharma companies and comparing their performance with four mid-to-large-cap companies, the study finds:
  • Annual projected pharma R&D returns continue to decline to 3.7 percent
  • Peak sales per asset fall 11.4 percent year-over-year since 2010
  • Costs to bring a product to market stabilize, from $1,576 million in 2015 to $1,539 million in 2016
Smaller pharma companies have seen a decline in overall performance, but on average they continue to outperform their larger counterparts, generating returns up to three times higher

Main factors influencing R&D returns
  • Maintain a consistent focus on a specific therapy area for stronger returns: There is a link between higher peak sales and company focus on a particular therapy area in order to treat a disease or illness.
  • End of the blockbuster: This has led to a situation with blockbuster costs without balancing blockbuster revenues, an equation which does not add up for long-term stakeholder value.
  • Smaller companies remain more effective: There is a negative correlation between the size of the company and both predicted returns, and cost per product. Lessons can be learned from smaller companies—as they are able to achieve higher R&D productivity.
  • Increase of M&A: Since 2013 there has been a steady decrease in the proportion of projected late-stage pipeline revenue derived from externally sourced products. This is a trend which has accelerated in 2016 as more of the products acquired as part of large-scale M&A in the late 2000s’ leave the late-stage pipelines. The decrease in returns highlights how companies are struggling to replace pipeline value through self-originated products.

Balancing the R&D equation

To supplement the quantitative analysis in this year’s report, the Deloitte US Center for Health Solutions conducted interviews with key industry executives. The following key lessons can be applied to help increase commercial success and reduce the cost to launch.
  • Increasing commercial success
  • Aim for therapy area focus
  • Target populations where value can be maximized
  • Adhere to robust target product profile
  • Generate evidence to support all stakeholder needs
  • Align end-to-end decision making across the organization
  • Increasing R&D productivity
  • Think small, win big decision-making
  • Strike the right balance of staff and resource
  • Lift the burden of data complexity


The pharmaceutical industry continues to face regulatory and reimbursement hurdles weighing on the research and development returns of pharmaceutical firms this year. The seventh annual pharmaceutical innovation study by the Deloitte UK Centre for Health Solutions looks at the challenges the industry faces in generating returns from its R&D investments while highlighting the key strategies to help increase pipeline value while reduce R&D costs to generate sustainable R&D returns.
Location: New York, NY, USA

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