Glucosamine
Glucosamine (C6H13NO5) is
natural amino sugar compound that is found within cartilage of our joints. It
is made up of chains of proteins and sugars bound together. Glucosamine is a
major precursor in the biochemical synthesis of glycosylated lipids and
proteins.
Apart from human cartilage, glucosamine is also a part of
the structures of chitin and polysaccharides chitosan which are building blocks
of exoskeletons of arthropods and crustaceans. Glucosamine is also a part of cell
walls of fungi and other higher organisms.
Why we need Glucosamine
Glucosamine is needed in our body for building cartilage
which a flexible and touch connective tissue found in many parts of our bodies.
Cartilage functions as cushion for joints and bones. Joint cartilage needs
glucosamine because it is important in production of glycosaminoglycan which is
a major component of joint cartilage. Sulfur is also needed in making and
repairing of cartilages. Therefore glucosamine is needed to incorporate sulfur
into the cartilages.
As we age, glucosamine levels fall. This leads to glucosamine
deficiency which can cause bone deterioration.
Glucosamine supplements
Glucosamine supplements are usually taken when glucosamine
levels fall in the body. Glucosamine supplements are taken orally and they come
in different forms such as:
·
Glucosamine sulfate
·
N-acetyl-glucosamine
·
Glucosamine hydrochloride
Glucosamine is the second most popular dietary supplement
after DHA or Omega 3. The most and commonly recommended form of glucosamine is
glucosamine sulfate.
What are the Sources
of Glucosamine?
The major natural food sources of glucosamine include:
1. Crustaceans
Most glucosamine supplements are commercially extracted from
exoskeletons or the outer shells of edible crustaceans such as crab, lobster,
crawfish, and shrimp. Though the shells are hard to chew and digest, one can
extract glucosamine by fully grinding the shells and then blending them into
pasta sauces, soups and stews.
2. Offal
All forms of cartilage contain natural glucosamine. Snout,
ears and joint tissues of butchered animals contain trace amounts of
glucosamine but these low nutrients and tough forms of offal are hardly
consumed.
3.
Other sources of glucosamine include:
o
Peasant meats
o
Hog’s head cheese
o
Fermented grain
How does glucosamine
work?
Most of the research done on glucosamine focused
specifically on the health benefits of glucosamine sulfate which is a natural
compound found in the human body. According to recent research, glucosamine
supplements obtained from natural sources such as bone broth have been found to
increase the amount of cartilage and synovial fluid. This helps in reducing
pain and joint breakdown during joint movement. Glucosamine helps in formation
of cartilage from compounds known as proteoglycans and aggrecan.
There is no recommended daily dose of glucosamine but the
majority do best with a dosage of 500-1500 milligrams per day. You can have
glucosamine alone or in a combination with other supplements such as Omega 3
and sulfate. The daily dosage major uses include:
·
Fighting of irritation to the bladder,
intestines and stomach
·
Treating leaky gut syndrome and inflammatory
bowel disease
·
Rebuilding stronger bones and tissues after
injuries and fractures
·
Preserving joint health
·
Reversing autoimmune reactions as well as lower
inflammation
·
Reducing tenderness and joint pain
·
Repairing and protecting gut lining
Health Benefits of
Glucosamine
As you have already learned, glucosamine is very important
in the formation of synovial fluid and joint cartilages. Below are some of the
health benefits you acquire from taking glucosamine supplements:
1. Treat osteoarthritis and improve joint
health
Glucosamine is very important when it comes to supporting
joint health and lessening of symptoms as a result of regenerative diseases
such as osteoarthritis. Old age naturally reduces the strength and durability
of joints and bones causing cartilage loss which is later followed by joint pain.
Glucosamine does not offer full relieve of osteoarthritis related symptoms but
can do better when compared to other supplements such as chondroitin.
Glucosamine is considered as the most effective compound in
treatment of arthritis as it slows down deterioration of joints when used in
long-term. Glucosamine also offers other
health benefits that prescribed painkillers cannot. They include benefits such
as improving digestive health and lowering of chronic inflammation.Glucosamine
impact in the body is different in different people but long-term users have
reported pain relief that has helped them avoid surgeries and eliminate
medication.
2.
Treats
IBD and improve digestion
Glucosamine supplementation is helpful in repairing the GI
tract and improving digestive function.
According to research, glucosamine has also been seen as an effective
leaky gut supplement.
Glucosamine supplements or natural/diet glucosamine help
repair damaged gut tissues and lower inflammation associated with inflammatory
bowel disease which is a painful and hard to treat disease. Glucosamine has
also been found to help in repairing of the lining of the bladder, stomach and
intestines.
According to scientists, glucosamine is a non-toxic and
inexpensive supplement that can be used in treatment of chronic inflammatory
bowel diseases (IBD) such as ulcerative colitis and Crohn’s disease. Glucosamine
deficiency has been associated with inflammatory bowel diseases in children.
Glucosamine helps restore the gastrointestinal tract
integrity by restoring the health of epithelial cells that help stop gut
permeability.
3. Eliminate bone pain
People with low bone density, bone pain and a history of
bone fractures can benefit from taking glucosamine supplements. Scientific
evidence suggests that glucosamine helps in preserving articular cartilage
surrounding the bones which help decrease bone pain and enhance physical
function.
Glucosamine help enhance activities in people who have bone
disorders or those at high risk of bone loss such as older women and the middle
aged individuals.
4. Relieve TMJ Symptoms
TMJ is a disease related to the temporo-manibular joint
found in the jaw. This disorder is common in young and middle-aged adults. This
disorder is characterized by frequent neck and jaw pains, headache,and sleeping
difficulties. Inflamed TMJ can cause trouble when talking, eating, walking and
other daily activities. According to scientific research, glucosamine used in
the long-term can help lower inflammation and pain on the jaw that can help you
sleep and chew well.
Other health benefits or uses of glucosamine include:
·
Treatment of:
o
Back pain
o
Multiple sclerosis
o
glaucoma
Some of the reported side effects of glucosamine
supplementation are infrequent and mild. They include:
·
Skin rashes
·
Stomach upsets
·
Diarrhea
·
Constipation
·
headache
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